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Anti-aging Topical Study Summary

OBJECTIVE OF THE TEST
To compare the effects of Formulas A and B on the skin moisture content, -elasticity and - surface parameters of 35 female Caucasian volunteers, 14, 28 and 42 days after the daily  application of both the formulas.

SUMMARY OF PROTOCOL
The study was carried out on the inner volar aspect of the non-dominant forearm of 35 Caucasian females, in compliance with the principles established by the World Medical Association in the Declaration of Helsinki.

The aim was to evaluate in a crossover double blind study, the effects on skin moisture content, skin surface parameters as well as skin elasticity of a formula containing active ingredients of a natural origin in comparison with a reference formula.

Thirty five healthy female volunteers aged from 35 to 65 years took part in the study. The washout period started 7 days before the study commenced. During the washout and study periods, the volunteers used only Dove soap and no other skin care products.

A recording area of (2cm x 6cm =12cm²) was marked on the non-dominant inner forearm.

SKIN HYDRATION

  • Both Formulas A and B hydrated the skin at all recording time intervals and can be regarded as moisturisers.
  • The hydrating effect of Formula A was superior to that of Formula B at all recording time intervals but this effect was statistical significant only 28 days post application.
  • Formula A when compared to Formula B, showed optimum hydrating effect at 28 days post application and maintained the effect up to 42 days 

SKIN ROUGHNESS

  • Formula A reduced-, while Formula B enhanced skin roughness at all recording intervals post application.
  • The difference in the effects of Formulas A and B on skin roughness was statistical significant at all recording intervals post application.

SKIN SCALINESS


Formula A reduced the skin scaliness at all recording intervals with the maximum effect recorded 28 days post application and maintained the effect up to 42 days post application. 

  • When compared to Formula A, Formula B had less effect on the reduction of scaliness.
  • The difference in the effects of Formulas A and B on the reduction of skin scaliness was statistical significant at all post application recording intervals.

SKIN ELASTICITY

  • Formula A showed a trend towards enhancing skin elasticity increasing from 14 days to 42 days post application.
  • Formula B had no significant effect on enhancing skin elasticity and the trend, moving from 14 days to 42 days post application, was in a negative direction.
  • Due to the small observed effect, and the huge inter subject variation, the differences in the effects of Formulas, A and B was not statistical significant (p values > 0.05).

 

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